/* ========================================
   XORTX Therapeutics Landing Page
   Colors: #006FF9, #376AD2, #1C479E
   Light Theme - Modern Pharma Design
======================================== */

:root {
  --primary: #006FF9;
  --primary-dark: #1C479E;
  --primary-mid: #376AD2;
  --accent: #00C2FF;
  --gradient: linear-gradient(135deg, #006FF9 0%, #1C479E 100%);
  --gradient-light: linear-gradient(135deg, #e8f4ff 0%, #f0f7ff 100%);
  --text-dark: #1a1a2e;
  --text-medium: #4a4a6a;
  --text-light: #6b7280;
  --bg-white: #ffffff;
  --bg-light: #f8fafd;
  --bg-section: #f0f5ff;
  --border-light: #e2e8f0;
  --shadow-sm: 0 2px 8px rgba(0, 111, 249, 0.06);
  --shadow-md: 0 8px 30px rgba(0, 111, 249, 0.1);
  --shadow-lg: 0 20px 60px rgba(0, 111, 249, 0.12);
  --shadow-card: 0 4px 20px rgba(0, 111, 249, 0.08);
  --radius-sm: 8px;
  --radius-md: 12px;
  --radius-lg: 20px;
  --radius-xl: 28px;
  --font: 'Inter', -apple-system, BlinkMacSystemFont, sans-serif;
  --transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
}

/* ===== RESET & BASE ===== */
*, *::before, *::after {
  margin: 0;
  padding: 0;
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
  font-size: 16px;
  scroll-padding-top: 80px;
  overflow-x: hidden;
}

body {
  font-family: var(--font);
  color: var(--text-dark);
  background: var(--bg-white);
  line-height: 1.7;
  overflow-x: hidden;
  -webkit-font-smoothing: antialiased;
}

a {
  color: var(--primary);
  text-decoration: none;
  transition: var(--transition);
}

a:hover {
  color: var(--primary-dark);
}

img {
  max-width: 100%;
  height: auto;
}

.container {
  max-width: 1200px;
  margin: 0 auto;
  padding: 0 24px;
}

/* ===== TYPOGRAPHY ===== */
h1, h2, h3, h4, h5, h6 {
  font-weight: 700;
  line-height: 1.3;
  color: var(--text-dark);
}

h1 { font-size: clamp(2rem, 4vw, 3.2rem); }
h2 { font-size: clamp(1.75rem, 3vw, 2.5rem); }
h3 { font-size: clamp(1.25rem, 2vw, 1.75rem); }
h4 { font-size: 1.25rem; }

p {
  color: var(--text-medium);
  line-height: 1.8;
}

.highlight {
  color: var(--primary);
}

.section-badge {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  background: linear-gradient(135deg, #e8f4ff, #dbeafe);
  color: var(--primary-dark);
  font-size: 0.8rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 1.5px;
  padding: 8px 18px;
  border-radius: 50px;
  margin-bottom: 16px;
}

.section-header {
  text-align: center;
  margin-bottom: 60px;
}

.section-header h2 {
  margin-top: 12px;
  margin-bottom: 16px;
}

.section-header p {
  max-width: 700px;
  margin: 0 auto;
  font-size: 1.05rem;
}

sup a.footnote {
  color: var(--primary);
  font-size: 0.7em;
  text-decoration: none;
}

/* ===== ANIMATIONS ===== */
@keyframes fadeInUp {
  from { opacity: 0; transform: translateY(40px); }
  to { opacity: 1; transform: translateY(0); }
}

@keyframes fadeInDown {
  from { opacity: 0; transform: translateY(-30px); }
  to { opacity: 1; transform: translateY(0); }
}

@keyframes fadeInLeft {
  from { opacity: 0; transform: translateX(-40px); }
  to { opacity: 1; transform: translateX(0); }
}

@keyframes fadeInRight {
  from { opacity: 0; transform: translateX(40px); }
  to { opacity: 1; transform: translateX(0); }
}

@keyframes scaleIn {
  from { opacity: 0; transform: scale(0.9); }
  to { opacity: 1; transform: scale(1); }
}

@keyframes pulse {
  0%, 100% { transform: scale(1); opacity: 0.8; }
  50% { transform: scale(1.05); opacity: 1; }
}

@keyframes float {
  0%, 100% { transform: translateY(0px) scale(1); opacity: 0.6; }
  25% { transform: translateY(-20px) scale(1.2); opacity: 1; }
  50% { transform: translateY(-30px) scale(0.8); opacity: 0.8; }
  75% { transform: translateY(-10px) scale(1.1); opacity: 1; }
}

@keyframes shimmer {
  0% { background-position: -200% center; }
  100% { background-position: 200% center; }
}

@keyframes rotate {
  from { transform: rotate(0deg); }
  to { transform: rotate(360deg); }
}

@keyframes morphBlob {
  0%, 100% { border-radius: 60% 40% 30% 70% / 60% 30% 70% 40%; }
  25% { border-radius: 30% 60% 70% 40% / 50% 60% 30% 60%; }
  50% { border-radius: 50% 60% 30% 60% / 30% 60% 70% 40%; }
  75% { border-radius: 60% 30% 50% 40% / 60% 40% 60% 30%; }
}

@keyframes gradientMove {
  0% { background-position: 0% 50%; }
  50% { background-position: 100% 50%; }
  100% { background-position: 0% 50%; }
}

@keyframes slideInScale {
  from { opacity: 0; transform: scale(0.8) translateY(20px); }
  to { opacity: 1; transform: scale(1) translateY(0); }
}

@keyframes countUp {
  from { opacity: 0; transform: translateY(20px); }
  to { opacity: 1; transform: translateY(0); }
}

/* Reveal on Scroll */
.reveal {
  opacity: 0;
  transform: translateY(30px);
  transition: opacity 0.8s cubic-bezier(0.4, 0, 0.2, 1), transform 0.8s cubic-bezier(0.4, 0, 0.2, 1);
}

.reveal.active {
  opacity: 1;
  transform: translateY(0);
}

.reveal-left {
  opacity: 0;
  transform: translateX(-40px);
  transition: opacity 0.8s ease, transform 0.8s ease;
}

.reveal-left.active {
  opacity: 1;
  transform: translateX(0);
}

.reveal-right {
  opacity: 0;
  transform: translateX(40px);
  transition: opacity 0.8s ease, transform 0.8s ease;
}

.reveal-right.active {
  opacity: 1;
  transform: translateX(0);
}

.stagger-1 { transition-delay: 0.1s; }
.stagger-2 { transition-delay: 0.2s; }
.stagger-3 { transition-delay: 0.3s; }
.stagger-4 { transition-delay: 0.4s; }
.stagger-5 { transition-delay: 0.5s; }
.stagger-6 { transition-delay: 0.6s; }

/* ===== NAVIGATION ===== */
.navbar {
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  z-index: 1000;
  padding: 5px 0;
  transition: var(--transition);
  background: transparent;
}

.navbar.scrolled {
  background: rgba(255, 255, 255, 0.95);
  backdrop-filter: blur(20px);
  box-shadow: 0 2px 20px rgba(0, 0, 0, 0.06);
  padding: 10px 0;
}

.navbar .container {
  display: flex;
  align-items: center;
  justify-content: space-between;
  max-width: 92%;
}

.nav-logo img {
  height: 80px;
  transition: var(--transition);
  filter: brightness(0) invert(1);
}

.navbar.scrolled .nav-logo img {
  filter: none;
}

.nav-advertorial {
  color: #fff;
  font-size: 0.72rem;
  font-weight: 600;
  letter-spacing: 1.5px;
  text-transform: uppercase;
  padding: 8px 18px;
  border: 1px solid rgba(255, 255, 255, 0.4);
  border-radius: 50px;
  transition: var(--transition);
  background: rgba(0, 112, 249, 0.123);
  backdrop-filter: blur(6px);
  display: inline-block;
  line-height: normal;
  margin-bottom: 20px;
  position: relative;
  z-index: 5;
}

.navbar.scrolled .nav-advertorial {
  color: var(--primary-dark);
  border-color: var(--primary);
  background: rgba(0, 111, 249, 0.08);
}

.nav-advertorial a{color: #fff;}

/* ===== HERO SECTION ===== */
.hero {
  position: relative;
  min-height: 100vh;
  display: flex;
  align-items: center;
  justify-content: flex-start;
  overflow: hidden;
  background: linear-gradient(160deg, #0a1628 0%, #1C479E 40%, #006FF9 100%);
  padding: 160px 0 80px;
}

.hero::after {
  content: '';
  position: absolute;
  top: 0;
  right: 0;
  width: 50%;
  height: 100%;
  background: url('../img/image_home.jpg') center/cover no-repeat;
  z-index: 2;
  opacity: 0.60;
  mask-image: linear-gradient(to right, transparent 0%, black 30%);
  -webkit-mask-image: linear-gradient(to right, transparent 0%, black 30%);
}

.hero::before {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  bottom: 0;
  background: 
    radial-gradient(circle at 20% 50%, rgba(0, 111, 249, 0.15) 0%, transparent 50%),
    radial-gradient(circle at 80% 20%, rgba(0, 194, 255, 0.1) 0%, transparent 40%),
    radial-gradient(circle at 60% 80%, rgba(55, 106, 210, 0.1) 0%, transparent 40%);
  z-index: 1;
}

.hero-bg-pattern {
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  bottom: 0;
  opacity: 0.06;
  background-image: url("data:image/svg+xml,%3Csvg width='60' height='60' viewBox='0 0 60 60' xmlns='http://www.w3.org/2000/svg'%3E%3Cg fill='none' fill-rule='evenodd'%3E%3Cg fill='%23ffffff' fill-opacity='1'%3E%3Cpath d='M36 34v-4h-2v4h-4v2h4v4h2v-4h4v-2h-4zm0-30V0h-2v4h-4v2h4v4h2V6h4V4h-4zM6 34v-4H4v4H0v2h4v4h2v-4h4v-2H6zM6 4V0H4v4H0v2h4v4h2V6h4V4H6z'/%3E%3C/g%3E%3C/g%3E%3C/svg%3E");
  background-size: 60px 60px;
  z-index: 1;
  animation: patternDrift 20s linear infinite, patternPulse 8s ease-in-out infinite;
}

@keyframes patternDrift {
  0% { background-position: 0 0; }
  100% { background-position: 60px 60px; }
}

@keyframes patternPulse {
  0%, 100% { opacity: 0.03; transform: scale(1); }
  50% { opacity: 0.08; transform: scale(1.02); }
}

.hero-blob {
  position: absolute;
  width: 600px;
  height: 600px;
  background: rgba(0, 194, 255, 0.06);
  border-radius: 50%;
  filter: blur(80px);
  animation: morphBlob 15s ease-in-out infinite;
  z-index: 1;
}

.hero-blob--1 {
  top: -200px;
  right: -200px;
}

.hero-blob--2 {
  bottom: -200px;
  left: -200px;
  background: rgba(0, 111, 249, 0.08);
  animation-delay: -5s;
}

.hero-particles {
  position: absolute;
  top: 0;
  left: 0;
  width: 100%;
  height: 100%;
  z-index: 1;
}

.hero-particle {
  position: absolute;
  width: 6px;
  height: 6px;
  background: rgba(255, 255, 255, 0.7);
  border-radius: 50%;
  animation: float 3s ease-in-out infinite;
  box-shadow: 0 0 8px rgba(0, 194, 255, 0.5), 0 0 16px rgba(0, 111, 249, 0.3);
}

.hero-particle:nth-child(1) { top: 20%; left: 10%; animation-delay: 0s; width: 8px; height: 8px; }
.hero-particle:nth-child(2) { top: 40%; left: 80%; animation-delay: 0.4s; width: 10px; height: 10px; }
.hero-particle:nth-child(3) { top: 60%; left: 30%; animation-delay: 0.8s; width: 7px; height: 7px; }
.hero-particle:nth-child(4) { top: 15%; left: 60%; animation-delay: 1.2s; width: 9px; height: 9px; }
.hero-particle:nth-child(5) { top: 75%; left: 70%; animation-delay: 1.6s; width: 6px; height: 6px; }
.hero-particle:nth-child(6) { top: 85%; left: 15%; animation-delay: 0.6s; width: 5px; height: 5px; }
.hero-particle:nth-child(7) { top: 30%; left: 90%; animation-delay: 1s; width: 8px; height: 8px; }
.hero-particle:nth-child(8) { top: 50%; left: 50%; animation-delay: 1.4s; width: 7px; height: 7px; }

.hero-content {
  position: relative;
  z-index: 10;
  text-align: left;
  max-width: 1200px;
  width: 80%;
  margin: 0;
  padding-left: 5%;
  padding-top: 0px;
}

.hero-ticker {
  display: inline-flex;
  align-items: center;
  gap: 14px;
  background: rgba(0, 194, 255, 0.12);
  border: 2px solid rgba(0, 194, 255, 0.4);
  padding: 16px 40px;
  border-radius: 60px 0;
  margin-bottom: 40px;
  backdrop-filter: blur(10px);
  box-shadow: 0 0 30px rgba(0, 194, 255, 0.15), inset 0 0 20px rgba(0, 194, 255, 0.05);
  animation: tickerGlow 3s ease-in-out infinite;
}

@keyframes tickerGlow {
  0%, 100% {
    box-shadow: 0 0 30px rgba(0, 194, 255, 0.15), inset 0 0 20px rgba(0, 194, 255, 0.05);
    border-color: rgba(0, 194, 255, 0.4);
  }
  50% {
    box-shadow: 0 0 50px rgba(0, 194, 255, 0.3), inset 0 0 30px rgba(0, 194, 255, 0.1), 0 0 80px rgba(0, 111, 249, 0.15);
    border-color: rgba(0, 194, 255, 0.7);
  }
}

.hero-ticker .dot {
  width: 12px;
  height: 12px;
  background: #00ff88;
  border-radius: 50%;
  animation: pulse 2s ease infinite;
  box-shadow: 0 0 10px rgba(0, 255, 136, 0.5);
}

.hero-ticker span {
  color: #fff;
  font-weight: 800;
  font-size: 1.5rem;
  letter-spacing: 2px;
  text-shadow: 0 0 20px rgba(0, 194, 255, 0.3);
}

.hero h1 {
  color: #fff;
  font-size: clamp(1.8rem, 3.5vw, 2.8rem);
  font-weight: 700;
  line-height: 1.4;
  margin-bottom: 24px;
  animation: fadeInUp 1s ease 0.4s forwards;
  opacity: 0;
  text-shadow: 0 2px 2px #0c296d;
}

.hero h1 .highlight {
  background: #9C27B0;
      color: #fff;
    display: inline;
    padding: 0 10px;
    text-shadow: 0 2px 2px #600370;
}

.hero-desc {
  color: rgba(255, 255, 255, 0.8);
  font-size: 1.05rem;
  line-height: 1.9;
  max-width: 100%;
  margin: 0 auto 40px;
  animation: fadeInUp 1s ease 0.6s forwards;
  opacity: 0;
}

.hero-compensation {
  position: absolute;
  bottom: 20px;
  left: 50%;
  transform: translateX(-50%);
  width: 90%;
  max-width: 900px;
  z-index: 10;
  color: rgba(255, 255, 255, 0.4);
  font-size: 0.65rem;
  text-align: center;
  line-height: 1.5;
}

#ct {
    position: absolute;
    bottom: 0;
    width: 100%;
    background: rgba(0, 0, 0, 0.5);
    padding: 5px 15px;
    border-radius: 0;
    font-size: 10px;
    line-height: 14px;
    z-index: 99;
    color: #fff;
    scroll-margin-top: 100px;
}

.nav-advertorial a {
  color: #fff;
  text-decoration: none;
  font-weight: 700;
}

/* ===== INVESTOR OVERVIEW ===== */
.investor-overview {
  padding: 100px 0;
  background: var(--bg-white);
  position: relative;
  overflow: hidden;
}

.investor-overview::before {
  content: '';
  position: absolute;
  top: 0;
  right: 0;
  width: 400px;
  height: 400px;
  background: radial-gradient(circle, rgba(0, 111, 249, 0.03), transparent);
  border-radius: 50%;
}

.overview-content {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 60px;
  align-items: center;
}

.overview-text p {
  margin-bottom: 20px;
  font-size: 1.1rem;
}

.overview-image {
  position: relative;
}

.overview-image img {
  border-radius: var(--radius-lg);
  box-shadow: var(--shadow-lg);
}
.overview-image::before {
  content: '';
  position: absolute;
  bottom: -20px;
  left: -20px;
  width: 100px;
  height: 100px;
  border: 3px solid var(--primary);
  border-radius: 40%;
  opacity: 0.2;
  z-index: 1;
  animation: rotateInfinite 12s linear infinite;
}
.overview-image::after {
  content: '';
  position: absolute;
  top: -20px;
  right: -20px;
  width: 100px;
  height: 100px;
  border: 3px solid var(--primary);
  border-radius: var(--radius-md);
  opacity: 0.2;
  z-index: -1;
  animation: rotateInfinite 12s linear infinite;
}

@keyframes rotateInfinite {
  0% { transform: rotate(0deg); }
  100% { transform: rotate(360deg); }
}

/* ===== KEY HIGHLIGHTS ===== */
.highlights-section {
  padding: 100px 0;
  background: linear-gradient(165deg, #070d1a 0%, #0d1b3e 40%, #0f2248 100%);
  position: relative;
  overflow: hidden;
}

.highlights-section::before {
  content: '';
  position: absolute;
  top: 0;
  right: 0;
  bottom: 0;
  width:100%;
  background: url('../img/background_image.jpg') right center / cover no-repeat;
  opacity: 1;
  mask-image: linear-gradient(to left, rgba(0,0,0,1) 0%, rgba(0,0,0,0) 100%);
  -webkit-mask-image: linear-gradient(to left, rgba(0,0,0,1) 0%, rgba(0,0,0,0) 100%);
  pointer-events: none;
}

.highlights-section::after {
  content: '';
  position: absolute;
  bottom: -30%;
  left: -10%;
  width: 500px;
  height: 500px;
  background: radial-gradient(circle, rgba(0, 194, 255, 0.08), transparent 70%);
  border-radius: 50%;
  pointer-events: none;
}

.highlights-section .section-header h2 {
  color: #fff;
}

.hl-grid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 24px;
}

.hl-card {
  position: relative;
  background: rgba(255, 255, 255, 0.04);
  backdrop-filter: blur(16px);
  -webkit-backdrop-filter: blur(16px);
  border: 1px solid rgba(255, 255, 255, 0.08);
  border-radius: var(--radius-lg);
  padding: 36px 32px;
  transition: all 0.4s cubic-bezier(0.4, 0, 0.2, 1);
  overflow: hidden;
}

.hl-card--wide {
  grid-column: span 2;
}

.hl-card-glow {
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  bottom: 0;
  background: radial-gradient(ellipse at 50% 0%, rgba(0, 111, 249, 0.08) 0%, transparent 60%);
  opacity: 0;
  transition: opacity 0.4s ease;
  pointer-events: none;
}

.hl-card:hover .hl-card-glow {
  opacity: 1;
}

.hl-card:hover {
  border-color: rgba(0, 111, 249, 0.3);
  transform: translateY(-4px);
  box-shadow: 0 20px 50px rgba(0, 0, 0, 0.3), 0 0 30px rgba(0, 111, 249, 0.1);
}

.hl-card-number {
  position: absolute;
  top: 20px;
  right: 24px;
  font-size: 3rem;
  font-weight: 900;
  background: linear-gradient(135deg, rgba(0, 111, 249, 0.2), rgba(0, 194, 255, 0.1));
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
  line-height: 1;
  pointer-events: none;
}

.hl-card-icon {
  width: 52px;
  height: 52px;
  background: linear-gradient(135deg, rgba(0, 111, 249, 0.15), rgba(0, 194, 255, 0.1));
  border: 1px solid rgba(0, 111, 249, 0.2);
  border-radius: var(--radius-md);
  display: flex;
  align-items: center;
  justify-content: center;
  margin-bottom: 20px;
  color: var(--accent);
}

.hl-card h4 {
  color: #fff;
  font-size: 1.1rem;
  font-weight: 700;
  margin-bottom: 12px;
}

.hl-card p {
  color: rgba(255, 255, 255, 0.6);
  font-size: 0.92rem;
  line-height: 1.8;
}

/* ===== STRATEGIC PIPELINE EXPANSION ===== */
.strategic-section {
  padding: 100px 0;
  background: var(--bg-white);
  position: relative;
}

.strategic-content {
  max-width: 900px;
  margin: 0 auto;
}

.strategic-quote {
  background: linear-gradient(135deg, #f8fbff 0%, #eef4ff 50%, #f0f7ff 100%);
  border: 1px solid rgba(0, 111, 249, 0.1);
  border-left: none;
  padding: 48px 52px 48px 60px;
  border-radius: 20px;
  margin: 40px 0;
  position: relative;
  overflow: hidden;
  box-shadow: 0 8px 40px rgba(0, 111, 249, 0.06), 0 1px 3px rgba(0, 0, 0, 0.04);
  transition: all 0.4s cubic-bezier(0.4, 0, 0.2, 1);
}

.strategic-quote:hover {
  box-shadow: 0 16px 60px rgba(0, 111, 249, 0.1), 0 2px 6px rgba(0, 0, 0, 0.04);
  transform: translateY(-2px);
}

.strategic-quote::before {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  width: 5px;
  height: 100%;
  background: linear-gradient(180deg, #006FF9, #00C2FF);
  border-radius: 5px 0 0 5px;
}

.strategic-quote::after {
  content: '\201C';
  position: absolute;
  top: 20px;
  right: 40px;
  font-size: 8rem;
  font-family: Georgia, 'Times New Roman', serif;
  color: rgba(0, 111, 249, 0.06);
  line-height: 1;
  pointer-events: none;
}

.strategic-quote p {
  font-style: italic;
  font-size: 1.1rem;
  color: #334155;
  line-height: 1.9;
  position: relative;
  z-index: 1;
}

.strategic-quote .quote-author {
  margin-top: 28px;
  display: flex;
  align-items: center;
  gap: 16px;
  padding-top: 24px;
  border-top: 1px solid rgba(0, 111, 249, 0.08);
  position: relative;
  z-index: 1;
}

.strategic-quote .quote-author-img {
  width: 56px;
  height: 56px;
  border-radius: 50%;
  object-fit: cover;
  border: 3px solid #fff;
  box-shadow: 0 4px 12px rgba(0, 111, 249, 0.15);
}

.strategic-quote .quote-author strong {
  display: block;
  font-size: 0.95rem;
  font-weight: 700;
  color: #0f172a;
  letter-spacing: -0.01em;
}

.strategic-quote .quote-author span {
  font-size: 0.8rem;
  color: #006FF9;
  font-weight: 600;
  letter-spacing: 0.02em;
}

/* ===== PROBLEM & SOLUTION ===== */
.problem-solution {
  padding-top: 100px;
  padding-bottom: 0;
  background: var(--bg-white) url("../img/line.png") top center repeat-x;
  position: relative;
  overflow: hidden;
}

.ps-panel {
  position: relative;
  min-height: 600px;
  display: flex;
  align-items: center;
  overflow: hidden;
}

.ps-panel-bg {
  position: absolute;
  inset: 0;
  background-size: cover;
  background-position: center;
  background-attachment: fixed;
  transition: transform 0.3s ease;
}

.ps-panel:hover .ps-panel-bg {
  transform: scale(1.02);
}

.ps-panel-overlay {
  position: absolute;
  inset: 0;
  z-index: 1;
}

.ps-panel--problem .ps-panel-overlay {
  background: linear-gradient(135deg, rgba(165, 13, 13, 0.88) 0%, rgba(30, 41, 59, 0.20) 50%, rgba(82, 10, 10, 0.6) 100%);
}

.ps-panel--solution .ps-panel-overlay {
  background: linear-gradient(135deg, rgba(6, 78, 59, 0.9) 0%, rgba(20, 83, 45, 0.20) 50%, rgba(21, 128, 61, 0.75) 100%);
}

.ps-panel-content {
  position: relative;
  z-index: 2;
  width: 100%;
  padding: 80px 5%;
}

.ps-panel--problem .ps-panel-content {
  display: flex;
  justify-content: flex-end;
}

.ps-panel--solution .ps-panel-content {
  display: flex;
  justify-content: flex-start;
}

.ps-floating-card {
  max-width: 680px;
  width: 100%;
  display: flex;
  border-radius: var(--radius-xl);
  overflow: hidden;
  backdrop-filter: blur(20px);
  -webkit-backdrop-filter: blur(20px);
  background: rgba(255, 255, 255, 0.12);
  border: 1px solid rgba(255, 255, 255, 0.2);
  box-shadow: 0 25px 60px rgba(0, 0, 0, 0.3), 0 0 80px rgba(0, 111, 249, 0.08);
  transform: translateY(0);
  transition: transform 0.4s ease, box-shadow 0.4s ease;
}

.ps-floating-card:hover {
  transform: translateY(-6px);
  box-shadow: 0 35px 80px rgba(0, 0, 0, 0.4), 0 0 100px rgba(0, 111, 249, 0.12);
}

.ps-card-accent {
  width: 6px;
  flex-shrink: 0;
}

.ps-panel--problem .ps-card-accent {
  background: linear-gradient(180deg, #ef4444, #dc2626, #b91c1c);
}

.ps-panel--solution .ps-card-accent {
  background: linear-gradient(180deg, #4ade80, #16a34a, #166534);
}

.ps-card-body {
  padding: 48px 40px;
}

.ps-label {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  font-size: 0.75rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 2px;
  padding: 8px 18px;
  border-radius: 50px;
  margin-bottom: 24px;
}

.ps-label-dot {
  width: 8px;
  height: 8px;
  border-radius: 50%;
}

.ps-label--problem {
  background: rgba(239, 68, 68, 0.15);
  color: #fca5a5;
  border: 1px solid rgba(239, 68, 68, 0.3);
}

.ps-label--problem .ps-label-dot {
  background: #ef4444;
  animation: pulse 2s ease infinite;
}

.ps-label--solution {
  background: rgba(74, 222, 128, 0.15);
  color: #86efac;
  border: 1px solid rgba(74, 222, 128, 0.3);
}

.ps-label--solution .ps-label-dot {
  background: #4ade80;
  animation: pulse 2s ease infinite;
}

.ps-card-body h3 {
  font-size: 1.6rem;
  font-weight: 800;
  margin-bottom: 20px;
  color: #fff;
}

.ps-card-body p {
  margin-bottom: 16px;
  font-size: 1rem;
  color: rgba(255, 255, 255, 0.99);
  line-height: 1.85;
}

.ps-card-body p strong {
  color: #fff;
  font-weight: 700;
}

.ps-card-body .footnote {
  color: #93e8ff;
}

/* ===== MARKET OPPORTUNITY ===== */
.market-section {
  padding: 100px 0;
  background: var(--bg-white);
  position: relative;
  overflow: hidden;
}

.market-cta {
  margin-top: 36px;
  padding: 28px 36px;
  background: linear-gradient(135deg, #006FF9 0%, #0055cc 100%);
  border-radius: 14px;
  position: relative;
  overflow: hidden;
  box-shadow: 0 8px 32px rgba(0, 111, 249, 0.25);
}

.market-cta::before {
  content: '';
  position: absolute;
  top: -50%;
  right: -20%;
  width: 300px;
  height: 300px;
  background: radial-gradient(circle, rgba(255,255,255,0.1), transparent 70%);
  border-radius: 50%;
  pointer-events: none;
}

.market-cta p {
  color: #ffffff;
  font-size: 1.05rem;
  font-weight: 700;
  line-height: 1.6;
  margin: 0;
  position: relative;
  z-index: 1;
}

.market-stats {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 24px;
  margin-bottom: 60px;
}

.stat-card {
  background: var(--bg-white);
  border: 1px solid var(--border-light);
  border-radius: var(--radius-lg);
  padding: 32px 24px;
  text-align: center;
  transition: var(--transition);
  position: relative;
  overflow: hidden;
}

.stat-card::after {
  content: '';
  position: absolute;
  bottom: 0;
  left: 0;
  right: 0;
  height: 3px;
  background: var(--gradient);
  opacity: 0;
  transition: opacity 0.3s ease;
}

.stat-card:hover::after {
  opacity: 1;
}

.stat-card:hover {
  transform: translateY(-4px);
  box-shadow: var(--shadow-md);
}

.stat-card .stat-number {
  font-size: 2.2rem;
  font-weight: 800;
  background: var(--gradient);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
  margin-bottom: 8px;
}

.stat-card .stat-label {
  font-size: 0.85rem;
  color: var(--text-light);
  font-weight: 500;
}

.market-content p {
  margin-bottom: 20px;
  font-size: 1.1rem;
}

/* ===== REASONS / TOP 10 ===== */
.reasons-section {
  padding: 120px 0;
  background: linear-gradient(180deg, #0a0f1e 0%, #0d1a2d 50%, #0a1628 100%);
  position: relative;
  overflow: hidden;
}

.reasons-section::before {
  content: '';
  position: absolute;
  inset: 0;
  background:
    radial-gradient(ellipse 600px 400px at 20% 30%, rgba(0, 111, 249, 0.08) 0%, transparent 70%),
    radial-gradient(ellipse 500px 300px at 80% 70%, rgba(0, 194, 255, 0.06) 0%, transparent 70%);
  pointer-events: none;
}

.reasons-section .section-header h2 {
  color: #ffffff;
}

.reasons-section .section-badge {
  background: rgba(0, 111, 249, 0.15);
  color: #60b4ff;
}

.reasons-grid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 20px;
  counter-reset: reason;
}

.reason-card {
  background: rgba(255, 255, 255, 0.03);
  backdrop-filter: blur(12px);
  -webkit-backdrop-filter: blur(12px);
  border-radius: 16px;
  padding: 32px 28px 28px;
  border: 1px solid rgba(255, 255, 255, 0.06);
  transition: all 0.4s cubic-bezier(0.4, 0, 0.2, 1);
  position: relative;
  counter-increment: reason;
  overflow: hidden;
}

.reason-card::before {
  content: counter(reason, decimal-leading-zero);
  position: absolute;
  top: -12px;
  right: 14px;
  font-size: 5rem;
  font-weight: 900;
  line-height: 1;
  pointer-events: none;
  background: linear-gradient(135deg, rgba(0, 194, 255, 0.9) 0%, rgba(0, 111, 249, 0.7) 50%, rgba(139, 92, 246, 0.5) 100%);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
  text-shadow: none;
  filter: drop-shadow(0 2px 4px rgba(0, 111, 249, 0.3)) drop-shadow(0 6px 12px rgba(0, 111, 249, 0.15));
  opacity: 0.85;
  transition: all 0.4s ease;
}

.reason-card:hover::before {
  opacity: 1;
  filter: drop-shadow(0 3px 6px rgba(0, 111, 249, 0.4)) drop-shadow(0 10px 20px rgba(0, 111, 249, 0.2));
  transform: translateY(-2px) scale(1.05);
}

.reason-card::after {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  height: 2px;
  background: linear-gradient(90deg, transparent, rgba(0, 111, 249, 0.4), rgba(0, 194, 255, 0.4), transparent);
  opacity: 0;
  transition: opacity 0.4s ease;
}

.reason-card:hover {
  transform: translateY(-6px);
  background: rgba(255, 255, 255, 0.06);
  border-color: rgba(0, 111, 249, 0.25);
  box-shadow:
    0 20px 60px rgba(0, 0, 0, 0.3),
    0 0 40px rgba(0, 111, 249, 0.08),
    inset 0 1px 0 rgba(255, 255, 255, 0.05);
}

.reason-card:hover::after {
  opacity: 1;
}

.reason-card h4 {
  font-size: 1.05rem;
  font-weight: 700;
  margin-bottom: 12px;
  padding-right: 50px;
  color: #ffffff;
  letter-spacing: -0.01em;
}

.reason-card p {
  font-size: 0.88rem;
  color: rgba(255, 255, 255, 0.6);
  line-height: 1.75;
}

.reason-card .reason-list {
  list-style: none;
  margin-top: 14px;
}

.reason-card .reason-list li {
  font-size: 0.88rem;
  color: rgba(255, 255, 255, 0.7);
  padding: 8px 0;
  padding-left: 24px;
  position: relative;
  border-bottom: 1px solid rgba(255, 255, 255, 0.04);
}

.reason-card .reason-list li:last-child {
  border-bottom: none;
}

.reason-card .reason-list li::before {
  content: '';
  position: absolute;
  left: 4px;
  top: 50%;
  transform: translateY(-50%);
  width: 8px;
  height: 8px;
  border-radius: 50%;
  background: linear-gradient(135deg, #006FF9, #00C2FF);
  box-shadow: 0 0 8px rgba(0, 194, 255, 0.4);
}

/* Featured reason cards (first two) */
.reason-card--featured {
  grid-column: span 2;
  background: linear-gradient(135deg, rgba(0, 111, 249, 0.08) 0%, rgba(0, 194, 255, 0.04) 100%);
  border-color: rgba(0, 111, 249, 0.15);
  padding: 40px 36px;
}

.reason-card--featured h4 {
  font-size: 1.2rem;
  color: #ffffff;
}

.reason-card--featured::after {
  opacity: 0.5;
}

/* Reason card icon */
.reason-icon {
  width: 44px;
  height: 44px;
  border-radius: 12px;
  background: linear-gradient(135deg, rgba(0, 111, 249, 0.15), rgba(0, 194, 255, 0.1));
  display: flex;
  align-items: center;
  justify-content: center;
  margin-bottom: 18px;
  border: 1px solid rgba(0, 111, 249, 0.2);
}

.reason-icon svg {
  width: 22px;
  height: 22px;
  stroke: #60b4ff;
  fill: none;
  stroke-width: 1.5;
}

/* ===== COMPANY OVERVIEW ===== */
.company-section {
  padding: 100px 0;
  background: url('../img/kidneysh10.jpg') center/cover no-repeat fixed;
  position: relative;
}

.company-section::before {
  content: '';
  position: absolute;
  inset: 0;
  background: radial-gradient(ellipse at center, rgba(255,255,255,0.95) 0%, rgba(255,255,255,0.6) 50%, transparent 100%);
}
.company-section .section-header h2{ text-shadow: 2px 1px #fff;}
.company-section .container {
  position: relative;
  z-index: 1;
}

.company-content {
  display: grid;
  grid-template-columns: 1.2fr 0.8fr;
  gap: 60px;
  align-items: start;
}

.company-text {
  background: rgba(255, 255, 255, 0.55);
  backdrop-filter: blur(16px);
  -webkit-backdrop-filter: blur(16px);
  border: 1px solid rgba(255, 255, 255, 0.6);
  border-radius: 16px;
  padding: 36px;
  box-shadow: 0 8px 32px rgba(0, 0, 0, 0.08);
}

.company-text p {
  margin-bottom: 20px;
  font-size: 1.1rem;
}

.company-sidebar {
  position: sticky;
  top: 100px;
}

.company-sidebar-card {
  background: var(--gradient);
  border-radius: var(--radius-lg);
  padding: 40px;
  color: #fff;
}

.company-sidebar-card h4 {
  color: #fff;
  font-size: 1.1rem;
  margin-bottom: 20px;
}

.company-sidebar-card p {
  color: rgba(255, 255, 255, 0.85);
  font-size: 0.9rem;
  line-height: 1.8;
}

/* ===== FUTURE GROWTH ===== */
.growth-section {
  padding: 80px 0;
  background: linear-gradient(135deg, #f0f7ff 0%, #f8fbff 50%, #eef6ff 100%);
  position: relative;
  overflow: hidden;
}

.growth-section::before {
  content: '';
  position: absolute;
  top: -100px;
  right: -100px;
  width: 400px;
  height: 400px;
  background: radial-gradient(circle, rgba(0, 111, 249, 0.06), transparent 70%);
  border-radius: 50%;
  pointer-events: none;
}

.growth-card {
  display: flex;
  gap: 40px;
  align-items: flex-start;
  background: #ffffff;
  border-radius: 24px;
  padding: 48px 52px;
  box-shadow: 0 4px 30px rgba(0, 111, 249, 0.06), 0 1px 3px rgba(0, 0, 0, 0.04);
  border: 1px solid rgba(0, 111, 249, 0.08);
  position: relative;
  overflow: hidden;
}

.growth-card::before {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  width: 100%;
  height: 4px;
  background: linear-gradient(90deg, #006FF9, #00C2FF, #10b981);
}

.growth-icon {
  flex-shrink: 0;
  width: 80px;
  height: 80px;
  display: flex;
  align-items: center;
  justify-content: center;
  background: linear-gradient(135deg, #006FF9, #00C2FF);
  border-radius: 20px;
  color: #ffffff;
  box-shadow: 0 8px 24px rgba(0, 111, 249, 0.25);
}

.growth-content h3 {
  font-size: 1.5rem;
  font-weight: 800;
  color: #0f172a;
  margin-bottom: 16px;
  letter-spacing: -0.02em;
}

.growth-content p {
  font-size: 0.95rem;
  color: #475569;
  line-height: 1.8;
  margin-bottom: 14px;
}

.growth-highlights {
  display: flex;
  gap: 24px;
  margin-top: 28px;
}

.growth-highlight-item {
  display: flex;
  align-items: center;
  gap: 12px;
  padding: 16px 24px;
  background: linear-gradient(135deg, #f0f7ff, #e8f4ff);
  border-radius: 14px;
  border: 1px solid rgba(0, 111, 249, 0.1);
}

.growth-highlight-number {
  font-size: 2rem;
  font-weight: 900;
  background: linear-gradient(135deg, #006FF9, #00C2FF);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
  line-height: 1;
}

.growth-highlight-label {
  font-size: 0.8rem;
  font-weight: 600;
  color: #475569;
  text-transform: uppercase;
  letter-spacing: 0.5px;
  line-height: 1.3;
}

@media (max-width: 768px) {
  .growth-card {
    flex-direction: column;
    padding: 32px 24px;
    gap: 24px;
  }

  .growth-highlights {
    flex-direction: column;
    gap: 12px;
  }
}

/* ===== CLINICAL PIPELINE ===== */
.pipeline-section {
  padding: 120px 0;
  background: linear-gradient(180deg, #0a0f1e 0%, #0d1a2d 50%, #0a1628 100%);
  position: relative;
  overflow: hidden;
}

.pipeline-section::before {
  content: '';
  position: absolute;
  inset: 0;
  background: radial-gradient(ellipse at 20% 50%, rgba(0, 111, 249, 0.04) 0%, transparent 60%),
              radial-gradient(ellipse at 80% 20%, rgba(16, 185, 129, 0.03) 0%, transparent 50%);
  pointer-events: none;
}

.pipeline-section .section-header h2 {
  color: #f1f5f9;
}

.pipeline-section .section-badge {
  background: rgba(255, 255, 255, 0.06);
  border: 1px solid rgba(255, 255, 255, 0.1);
  color: rgba(255, 255, 255, 0.8);
}

/* Pipeline progress bar at top */
.pipeline-progress {
  display: flex;
  align-items: center;
  justify-content: space-between;
  margin-bottom: 60px;
  padding: 0 20px;
  position: relative;
}

.pipeline-progress::before {
  content: '';
  position: absolute;
  top: 50%;
  left: 60px;
  right: 60px;
  height: 3px;
  background: rgba(255, 255, 255, 0.1);
  border-radius: 2px;
  transform: translateY(-50%);
}

.pipeline-progress::after {
  content: '';
  position: absolute;
  top: 50%;
  left: 60px;
  width: 20%;
  height: 3px;
  background: linear-gradient(90deg, #10b981, #006FF9);
  border-radius: 2px;
  transform: translateY(-50%);
  transition: width 0.8s cubic-bezier(0.4, 0, 0.2, 1);
}

.pipeline-progress-step {
  position: relative;
  z-index: 1;
  display: flex;
  flex-direction: column;
  align-items: center;
  gap: 10px;
}

.pipeline-progress-dot {
  width: 18px;
  height: 18px;
  border-radius: 50%;
  border: 3px solid rgba(255, 255, 255, 0.2);
  background: #0d1a2d;
  transition: all 0.3s ease;
}

.pipeline-progress-dot--active {
  border-color: #10b981;
  background: #10b981;
  box-shadow: 0 0 0 4px rgba(16, 185, 129, 0.15);
}

.pipeline-progress-dot--current {
  border-color: #006FF9;
  background: #006FF9;
  box-shadow: 0 0 0 4px rgba(0, 111, 249, 0.15);
}

.pipeline-progress-dot--upcoming {
  border-color: rgba(255, 255, 255, 0.2);
  background: #0d1a2d;
}

.pipeline-progress-label {
  font-size: 0.68rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.8px;
  color: rgba(255, 255, 255, 0.5);
  white-space: nowrap;
}

/* Pipeline grid */
.pipeline-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 0;
  position: relative;
  border-left: 2px solid rgba(255, 255, 255, 0.1);
  margin-left: 40px;
  padding-left: 0;
}

.pipeline-card {
  background: rgba(255, 255, 255, 0.03);
  backdrop-filter: blur(10px);
  border-radius: 16px;
  padding: 0;
  margin-left: 40px;
  margin-bottom: 24px;
  box-shadow: 0 2px 20px rgba(0, 0, 0, 0.2);
  border: 1px solid rgba(255, 255, 255, 0.08);
  transition: all 0.35s cubic-bezier(0.4, 0, 0.2, 1);
  position: relative;
  overflow: hidden;
}

.pipeline-card::before {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  width: 5px;
  height: 100%;
}

.pipeline-card::after {
  content: '';
  position: absolute;
  top: 36px;
  left: -42px;
  width: 16px;
  height: 16px;
  border-radius: 50%;
  border: 3px solid;
  background: #0d1a2d;
  z-index: 2;
}

.pipeline-card:hover {
  box-shadow: 0 12px 40px rgba(0, 0, 0, 0.4);
  transform: translateX(6px);
  background: rgba(255, 255, 255, 0.06);
  border-color: transparent;
}

/* Stage colors */
.pipeline-card--nda::before { background: linear-gradient(180deg, #10b981, #059669); }
.pipeline-card--nda::after { border-color: #10b981; }
.pipeline-card--nda:hover { border-color: rgba(16, 185, 129, 0.3); }

.pipeline-card--clinical::before { background: linear-gradient(180deg, #006FF9, #0055cc); }
.pipeline-card--clinical::after { border-color: #006FF9; }
.pipeline-card--clinical:hover { border-color: rgba(0, 111, 249, 0.3); }

.pipeline-card--preclinical::before { background: linear-gradient(180deg, #f59e0b, #d97706); }
.pipeline-card--preclinical::after { border-color: #f59e0b; }
.pipeline-card--preclinical:hover { border-color: rgba(245, 158, 11, 0.3); }

.pipeline-card--preind::before { background: linear-gradient(180deg, #8b5cf6, #7c3aed); }
.pipeline-card--preind::after { border-color: #8b5cf6; }
.pipeline-card--preind:hover { border-color: rgba(139, 92, 246, 0.3); }

/* Card body */
.pipeline-card-body {
  padding: 32px 36px;
}

.pipeline-card .pipeline-tag {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  font-size: 0.68rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 1px;
  padding: 5px 12px;
  border-radius: 6px;
  margin-bottom: 12px;
}

.pipeline-tag--nda {
  background: rgba(16, 185, 129, 0.15);
  color: #34d399;
}

.pipeline-tag--clinical {
  background: rgba(0, 111, 249, 0.12);
  color: #60a5fa;
}

.pipeline-tag--preclinical {
  background: rgba(245, 158, 11, 0.12);
  color: #fbbf24;
}

.pipeline-tag--preind {
  background: rgba(139, 92, 246, 0.12);
  color: #a78bfa;
}

.pipeline-card h3 {
  margin-bottom: 12px;
  font-size: 1.2rem;
  font-weight: 700;
  color: #f1f5f9;
  letter-spacing: -0.02em;
}

.pipeline-card p {
  margin-bottom: 10px;
  font-size: 0.88rem;
  color: rgba(255, 255, 255, 0.6);
  line-height: 1.75;
}

.pipeline-card .learn-more {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  color: #60a5fa;
  font-weight: 600;
  font-size: 0.84rem;
  margin-top: 8px;
  transition: all 0.3s ease;
}

.pipeline-card .learn-more:hover {
  gap: 12px;
}

/* Pipeline market value badge */
.pipeline-market {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  margin-top: 14px;
  padding: 10px 16px;
  background: rgba(255, 255, 255, 0.05);
  border-radius: 10px;
  border: 1px solid rgba(255, 255, 255, 0.1);
}

.pipeline-market-label {
  font-size: 0.72rem;
  font-weight: 600;
  color: rgba(255, 255, 255, 0.5);
  text-transform: uppercase;
  letter-spacing: 0.5px;
}

.pipeline-market-value {
  font-size: 1.1rem;
  font-weight: 800;
  color: #60a5fa;
}

/* Lead card highlight */
.pipeline-card--lead {
  border: 1px solid rgba(16, 185, 129, 0.2);
  background: linear-gradient(135deg, rgba(16, 185, 129, 0.05) 0%, rgba(16, 185, 129, 0.02) 100%);
}

.pipeline-card--lead .pipeline-card-body {
  padding: 36px 40px;
}

/* Pipeline Animations & Interactivity */
.pipeline-progress-step {
  cursor: pointer;
  transition: transform 0.3s ease;
}

.pipeline-progress-step:hover {
  transform: scale(1.1);
}

.pipeline-progress-step:hover .pipeline-progress-dot {
  box-shadow: 0 0 0 6px rgba(0, 111, 249, 0.2);
}

.pipeline-step--active .pipeline-progress-dot {
  animation: pulseDot 1.5s ease-in-out infinite;
}

.pipeline-step--passed .pipeline-progress-dot {
  background: #10b981 !important;
  border-color: #10b981 !important;
}

.pipeline-step--active .pipeline-progress-label {
  color: #60a5fa;
  font-weight: 800;
}

@keyframes pulseDot {
  0%, 100% { box-shadow: 0 0 0 4px rgba(0, 111, 249, 0.15); }
  50% { box-shadow: 0 0 0 8px rgba(0, 111, 249, 0.25); }
}

/* Card entrance animation */
.pipeline-card {
  opacity: 0;
  transform: translateX(-30px);
  transition: all 0.6s cubic-bezier(0.4, 0, 0.2, 1);
}

.pipeline-card.active,
.pipeline-card.reveal.active {
  opacity: 1;
  transform: translateX(0);
}

.pipeline-grid .pipeline-card:nth-child(1) { transition-delay: 0.1s; }
.pipeline-grid .pipeline-card:nth-child(2) { transition-delay: 0.2s; }
.pipeline-grid .pipeline-card:nth-child(3) { transition-delay: 0.3s; }
.pipeline-grid .pipeline-card:nth-child(4) { transition-delay: 0.4s; }
.pipeline-grid .pipeline-card:nth-child(5) { transition-delay: 0.5s; }

/* Active card highlight */
.pipeline-card--active {
  box-shadow: 0 12px 40px rgba(0, 111, 249, 0.2) !important;
  border-color: rgba(0, 111, 249, 0.4) !important;
  background: rgba(0, 111, 249, 0.08) !important;
  transform: translateX(8px) !important;
}

.pipeline-card--active::before {
  animation: shimmerBar 1.5s ease-in-out;
}

@keyframes shimmerBar {
  0% { opacity: 0.5; }
  50% { opacity: 1; filter: brightness(1.3); }
  100% { opacity: 1; filter: brightness(1); }
}

/* Timeline line animation */
.pipeline-grid {
  border-image: linear-gradient(to bottom, rgba(255,255,255,0.1), rgba(255,255,255,0.1)) 1;
  transition: border-image 1s ease;
}

.pipeline-grid--animated {
  border-image: linear-gradient(to bottom, #10b981, #006FF9, #f59e0b, #8b5cf6) 1;
}

/* Timeline dot animation when card visible */
.pipeline-card.active::after,
.pipeline-card.reveal.active::after {
  animation: popIn 0.4s cubic-bezier(0.68, -0.55, 0.265, 1.55) forwards;
}

@keyframes popIn {
  0% { transform: scale(0); }
  100% { transform: scale(1); }
}

/* Hover effect for pipeline card - clickable feel */
.pipeline-card .learn-more {
  position: relative;
  overflow: hidden;
}

.pipeline-card .learn-more::after {
  content: '';
  position: absolute;
  bottom: -2px;
  left: 0;
  width: 0;
  height: 2px;
  background: #60a5fa;
  transition: width 0.3s ease;
}

.pipeline-card:hover .learn-more::after {
  width: 100%;
}

/* Progress bar fill animation */
.pipeline-progress::after {
  transition: width 0.8s cubic-bezier(0.4, 0, 0.2, 1);
}

.pipeline-progress[data-progress="1"]::after { width: 20%; }
.pipeline-progress[data-progress="2"]::after { width: 40%; }
.pipeline-progress[data-progress="3"]::after { width: 60%; }
.pipeline-progress[data-progress="4"]::after { width: 80%; }
.pipeline-progress[data-progress="5"]::after { width: calc(100% - 120px); }

/* ===== CLINICAL PIPELINE CHART ===== */
.pipeline-chart-section {
  padding: 100px 0;
  background: #f0f4f8;
}

.pipeline-chart-section .section-header h2 {
  color: #1a2744;
}

.pipeline-chart-section .section-badge {
  background: rgba(0, 111, 249, 0.08);
  border: 1px solid rgba(0, 111, 249, 0.2);
  color: #006FF9;
}

.pipeline-chart {
  background: #ffffff;
  border-radius: 8px;
  overflow: hidden;
  box-shadow: 0 2px 16px rgba(0, 0, 0, 0.06);
}

/* Header row */
.pipeline-chart-header {
  display: grid;
  grid-template-columns: 200px 1fr;
}

.pipeline-chart-label-col {
  background: transparent;
}

.pipeline-chart-phases {
  display: grid;
  grid-template-columns: repeat(5, 1fr);
}

.pipeline-phase-col {
  background: #1a2744;
  color: #ffffff;
  font-size: 0.75rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.5px;
  text-align: center;
  padding: 14px 8px;
  border-right: 1px solid rgba(255, 255, 255, 0.15);
}

.pipeline-phase-col:last-child {
  border-right: none;
}

/* Rows */
.pipeline-chart-row {
  display: grid;
  grid-template-columns: 200px 1fr;
  border-bottom: 1px solid #e2e8f0;
}

.pipeline-chart-row:last-child {
  border-bottom: none;
}

.pipeline-chart-drug {
  padding: 24px 20px;
  display: flex;
  flex-direction: column;
  justify-content: center;
  border-right: 1px solid #e2e8f0;
}

.pipeline-chart-drug strong {
  font-size: 0.95rem;
  font-weight: 700;
  color: #1a2744;
  margin-bottom: 2px;
}

.pipeline-chart-drug span {
  font-size: 0.75rem;
  color: #5a6a7e;
  line-height: 1.3;
}

/* Track area */
.pipeline-chart-track {
  position: relative;
  min-height: 72px;
  display: flex;
  align-items: center;
}

.pipeline-grid-lines {
  position: absolute;
  inset: 0;
  display: grid;
  grid-template-columns: repeat(5, 1fr);
  pointer-events: none;
}

.pipeline-grid-lines span {
  border-right: 1px solid #e2e8f0;
}

.pipeline-grid-lines span:last-child {
  border-right: none;
}

/* Arrow bars */
.pipeline-arrow {
  position: absolute;
  height: 28px;
  display: flex;
  align-items: center;
  justify-content: center;
}

.pipeline-arrow::after {
  content: '';
  position: absolute;
  right: -14px;
  top: 0;
  width: 0;
  height: 0;
  border-top: 14px solid transparent;
  border-bottom: 14px solid transparent;
}

.pipeline-arrow-text {
  font-size: 0.72rem;
  font-weight: 600;
  color: #ffffff;
  letter-spacing: 0.3px;
  position: relative;
  z-index: 1;
}

/* XRx-026: Starts at left edge of Preclinical, arrow tip reaches end of Approval */
.pipeline-arrow--026 {
  left: 0%;
  right: 22%;
  background: linear-gradient(90deg, #1a4a8a 0%, #3a7fd5 40%, #6aade8 100%);
  border-radius: 2px 0 0 2px;
}

.pipeline-arrow--026::after {
  border-left: 14px solid #6aade8;
}

/* XRx-008: Starts at left edge of Preclinical, arrow tip reaches end of Phase III (80%) */
.pipeline-arrow--008 {
  left: 0%;
  right: 42%;
  background: linear-gradient(90deg, #1a5a9e 0%, #3d8ae0 50%, #5ba3e8 100%);
  border-radius: 2px 0 0 2px;
}

.pipeline-arrow--008::after {
  border-left: 14px solid #5ba3e8;
}

/* XRx-101: Starts slightly into Preclinical, arrow tip reaches end of Phase III (80%) */
.pipeline-arrow--101 {
  left: 0%;
  right: 42%;
  background: linear-gradient(90deg, #2a6ab0 0%, #4d96dc 50%, #70b4ec 100%);
  border-radius: 2px 0 0 2px;
}

.pipeline-arrow--101::after {
  border-left: 14px solid #70b4ec;
}

/* XRx-225: Small arrow only in Preclinical */
.pipeline-arrow--225 {
  left: 0%;
  width: 14%;
  background: linear-gradient(90deg, #4a7fb5, #7eb3d8);
  border-radius: 2px 0 0 2px;
}

.pipeline-arrow--225::after {
  border-left: 14px solid #7eb3d8;
}

@media (max-width: 768px) {
  .pipeline-chart {
    overflow-x: auto;
  }

  .pipeline-chart-header,
  .pipeline-chart-row {
    grid-template-columns: 150px 1fr;
    min-width: 650px;
  }

  .pipeline-chart-drug {
    padding: 16px 12px;
  }

  .pipeline-chart-drug strong {
    font-size: 0.8rem;
  }

  .pipeline-chart-drug span {
    font-size: 0.68rem;
  }

  .pipeline-arrow {
    height: 22px;
  }

  .pipeline-arrow::after {
    right: -11px;
    border-top-width: 11px;
    border-bottom-width: 11px;
    border-left-width: 11px;
  }

  .pipeline-arrow-text {
    font-size: 0.6rem;
  }
}

/* ===== XRx-026 GOUT OVERVIEW ===== */
.gout-section {
  padding: 100px 0;
  background: #ffffff;
}

.gout-section .section-header h2 {
  color: #1a2744;
}

.gout-section .section-badge {
  background: rgba(0, 111, 249, 0.08);
  border: 1px solid rgba(0, 111, 249, 0.2);
  color: #006FF9;
}

.gout-content {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 48px;
  align-items: center;
}

.gout-image {
  border-radius: 12px;
  overflow: hidden;
}

.gout-image img {
  width: 100%;
  height: auto;
  display: block;
}

.gout-facts-list {
  list-style: none;
  padding: 0;
  margin: 0;
  display: flex;
  flex-direction: column;
  gap: 24px;
}

.gout-facts-list li {
  padding-left: 20px;
  border-left: 3px solid #006FF9;
}

.gout-facts-list li strong {
  display: block;
  font-size: 1.05rem;
  font-weight: 700;
  color: #1a2744;
  line-height: 1.4;
}

.gout-facts-list li span {
  display: block;
  font-size: 0.9rem;
  color: #4a5568;
  margin-top: 4px;
  padding-left: 8px;
}

@media (max-width: 768px) {
  .gout-content {
    grid-template-columns: 1fr;
    gap: 32px;
  }

  .gout-facts-list li strong {
    font-size: 0.95rem;
  }
}

/* ===== MARKET OPPORTUNITY: FEBUXOSTAT ===== */
.febuxostat-section {
  padding-top: 80px;
}

.febuxostat-section .section-header h2 {
  color: #1a2744;
}

.febuxostat-section .section-badge {
  background: rgba(0, 111, 249, 0.08);
  border: 1px solid rgba(0, 111, 249, 0.2);
  color: #006FF9;
}

.febuxostat-content {
  max-width: 900px;
  margin: 0 auto;
}

.febuxostat-image {
  border-radius: 8px;
  overflow: hidden;
  margin-bottom: 36px;
  box-shadow: 0 2px 16px rgba(0, 0, 0, 0.06);
  border: 1px solid #e2e8f0;
}

.febuxostat-image img {
  width: 100%;
  height: auto;
  display: block;
}

.febuxostat-bullets ul {
  list-style: none;
  padding: 0;
  margin: 0 0 28px 0;
  display: flex;
  flex-direction: column;
  gap: 16px;
}

.febuxostat-bullets ul li {
  font-size: 1.1rem;
  color: #1a2744;
  line-height: 1.5;
  padding-left: 20px;
  position: relative;
}

.febuxostat-bullets ul li::before {
  content: '\2022';
  position: absolute;
  left: 0;
  color: #006FF9;
  font-size: 1.3rem;
  line-height: 1.2;
}

.febuxostat-bullets ul li strong {
  color: #1a2744;
  font-weight: 700;
}

.febuxostat-gap-banner {
  background: #1a2744;
  border-radius: 8px;
  padding: 18px 28px;
}

.febuxostat-gap-banner p {
  color: #ffffff;
  font-size: 1.1rem;
  font-weight: 700;
  margin: 0;
  text-align: center;
}

@media (max-width: 768px) {
  .febuxostat-content {
    max-width: 100%;
  }

  .febuxostat-bullets ul li {
    font-size: 0.9rem;
  }

  .febuxostat-gap-banner p {
    font-size: 0.95rem;
  }
}

/* ===== OXYPURINOL SAFETY ===== */
.oxypurinol-section {
  padding-top: 80px;
  position: relative;
}

.oxypurinol-section .section-header h2 {
  color: #1a2744;
}

.oxypurinol-section .section-badge {
  background: rgba(0, 111, 249, 0.08);
  border: 1px solid rgba(0, 111, 249, 0.2);
  color: #006FF9;
}

.oxy-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 48px;
  align-items: start;
}

/* Fact cards */
.oxy-facts {
  display: flex;
  flex-direction: column;
  gap: 16px;
}

.oxy-fact-card {
  display: flex;
  align-items: flex-start;
  gap: 16px;
  padding: 20px;
  background: #f8fafc;
  border: 1px solid #e2e8f0;
  border-radius: 12px;
  transition: all 0.3s ease;
}

.oxy-fact-card:hover {
  background: #f0f7ff;
  border-color: rgba(0, 111, 249, 0.2);
  transform: translateX(4px);
  box-shadow: 0 4px 16px rgba(0, 111, 249, 0.08);
}

.oxy-fact-icon {
  flex-shrink: 0;
  width: 40px;
  height: 40px;
  display: flex;
  align-items: center;
  justify-content: center;
  background: rgba(0, 111, 249, 0.1);
  border-radius: 10px;
  color: #006FF9;
}

.oxy-fact-card p {
  font-size: 0.9rem;
  color: #4a5568;
  line-height: 1.6;
  margin: 0;
}

.oxy-fact-card p strong {
  color: #1a2744;
}

/* Comparison section */
.oxy-comparison {
  background: #f8fafc;
  border: 1px solid #e2e8f0;
  border-radius: 16px;
  padding: 32px;
}

.oxy-comparison-title {
  font-size: 1.1rem;
  font-weight: 700;
  color: #1a2744;
  margin: 0 0 4px 0;
  text-align: center;
}

.oxy-study-label {
  font-size: 0.78rem;
  color: #6b7280;
  text-align: center;
  margin: 0 0 24px 0;
}

.oxy-compare-row {
  display: grid;
  grid-template-columns: 140px 1fr 1fr;
  gap: 12px;
  align-items: center;
  padding: 14px 0;
  border-bottom: 1px solid #e8ecf1;
}

.oxy-compare-row:last-of-type {
  border-bottom: none;
}

.oxy-compare-header {
  padding-bottom: 8px;
  border-bottom: 1px solid #cbd5e1;
}

.oxy-compare-header .oxy-compare-allo,
.oxy-compare-header .oxy-compare-oxy {
  font-size: 0.72rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.5px;
  color: #6b7280;
}

.oxy-compare-name {
  font-size: 0.82rem;
  color: #4a5568;
  font-weight: 500;
}

.oxy-compare-allo,
.oxy-compare-oxy {
  display: flex;
  align-items: center;
  gap: 8px;
  font-size: 0.9rem;
  color: #1a2744;
  font-weight: 600;
}

.oxy-bar {
  height: 6px;
  border-radius: 3px;
  display: inline-block;
  min-width: 8px;
}

.oxy-bar--bad {
  background: linear-gradient(90deg, #ef4444, #f87171);
}

.oxy-bar--good {
  background: linear-gradient(90deg, #22c55e, #4ade80);
}

.oxy-compare-row--highlight {
  background: rgba(34, 197, 94, 0.06);
  border-radius: 8px;
  padding: 14px 12px;
  margin-top: 4px;
  border: 1px solid rgba(34, 197, 94, 0.2);
}

.oxy-compare-row--highlight .oxy-compare-oxy strong {
  color: #16a34a;
  font-size: 1.1rem;
}

/* Callout */
.oxy-callout {
  margin-top: 24px;
  background: linear-gradient(135deg, #006FF9, #1C479E);
  border-radius: 12px;
  padding: 20px 24px;
  display: flex;
  align-items: center;
  gap: 16px;
}

.oxy-callout-number {
  font-size: 2rem;
  font-weight: 900;
  color: #ffffff;
  flex-shrink: 0;
}

.oxy-callout p {
  font-size: 0.85rem;
  color: rgba(255, 255, 255, 0.9);
  line-height: 1.5;
  margin: 0;
  font-weight: 500;
}

.oxy-footnote {
  font-size: 0.72rem;
  color: #6b7280;
  margin-top: 16px;
  font-style: italic;
}

@media (max-width: 768px) {
  .oxy-grid {
    grid-template-columns: 1fr;
    gap: 32px;
  }

  .oxy-compare-row {
    grid-template-columns: 100px 1fr 1fr;
    gap: 8px;
  }

  .oxy-compare-name {
    font-size: 0.75rem;
  }

  .oxy-fact-card {
    padding: 16px;
  }

  .oxy-comparison {
    padding: 24px 16px;
  }
}

/* ===== LEARN MORE BUTTON ===== */
.btn-learnmore {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  padding: 16px 36px;
  background: linear-gradient(135deg, #006FF9 0%, #1C479E 100%);
  color: #ffffff;
  font-size: 0.95rem;
  font-weight: 700;
  text-decoration: none;
  border-radius: 50px;
  letter-spacing: 0.3px;
  transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
  box-shadow: 0 4px 20px rgba(0, 111, 249, 0.3);
  position: relative;
  overflow: hidden;
}

.btn-learnmore::before {
  content: '';
  position: absolute;
  top: 0;
  left: -100%;
  width: 100%;
  height: 100%;
  background: linear-gradient(90deg, transparent, rgba(255,255,255,0.2), transparent);
  transition: left 0.5s ease;
}

.btn-learnmore:hover::before {
  left: 100%;
}

.btn-learnmore:hover {
  transform: translateY(-3px);
  box-shadow: 0 8px 32px rgba(0, 111, 249, 0.4);
  color: #ffffff;
  background: linear-gradient(135deg, #0080ff 0%, #2558b8 100%);
}

.btn-learnmore:active {
  transform: translateY(-1px);
  box-shadow: 0 4px 16px rgba(0, 111, 249, 0.3);
}

/* ===== GOUT COMPETITIVE LANDSCAPE ===== */
.gout-landscape-section, .gout-plan-section {
  padding-top: 80px;
    }

.gout-landscape-section .section-header h2,
.gout-plan-section .section-header h2 {
  color: #1a2744;
}

.gout-landscape-section .section-badge {
  background: rgba(0, 111, 249, 0.08);
  border: 1px solid rgba(0, 111, 249, 0.2);
  color: #006FF9;
}

.landscape-table {
  max-width: 100%;
  margin: 0 auto;
  background: #ffffff;
  border-radius: 12px;
  overflow: hidden;
  box-shadow: 0 2px 16px rgba(0, 0, 0, 0.06);
  border: 1px solid #e2e8f0;
}

.landscape-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 16px 32px;
  background: #f1f5f9;
  border-bottom: 2px solid #cbd5e1;
}

.landscape-col-drug,
.landscape-col-status {
  font-size: 0.78rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 1px;
  color: #475569;
}

.landscape-row {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 24px 32px;
  border-bottom: 1px solid #e8ecf1;
  transition: background 0.2s ease;
}

.landscape-row:last-child {
  border-bottom: none;
}

.landscape-row:hover {
  background: #f8fafc;
}

.landscape-row--highlight {
  background: rgba(0, 111, 249, 0.03);
  border-left: 4px solid #006FF9;
}

.landscape-row--highlight:hover {
  background: rgba(0, 111, 249, 0.06);
}

.landscape-drug {
  display: flex;
  flex-direction: column;
  gap: 2px;
}

.landscape-drug strong {
  font-size: 1.1rem;
  font-weight: 700;
  color: #1a2744;
}

.landscape-drug span {
  font-size: 0.82rem;
  color: #6b7280;
  line-height: 1.4;
}

.landscape-status {
  text-align: right;
  display: flex;
  flex-direction: column;
  align-items: flex-end;
  gap: 4px;
  max-width: 240px;
}

.landscape-status--green {
  font-size: 0.88rem;
  font-weight: 700;
  color: #166534;
}

.landscape-status--red {
  font-size: 0.8rem;
  font-weight: 600;
  color: #dc2626;
  line-height: 1.4;
}

@media (max-width: 768px) {
  .landscape-row {
    flex-direction: column;
    align-items: flex-start;
    gap: 12px;
    padding: 20px 20px;
  }

  .landscape-status {
    text-align: left;
    align-items: flex-start;
  }

  .landscape-header {
    padding: 14px 20px;
  }
}

/* ===== PROPRIETARY OXYPURINOL FORMULATION ===== */
.formulation-section {
  padding-top: 80px;
}

.formulation-section .section-header h2 {
  color: #1a2744;
}

.formulation-section .section-badge {
  background: rgba(0, 111, 249, 0.08);
  border: 1px solid rgba(0, 111, 249, 0.2);
  color: #006FF9;
}

.formulation-grid {
  display: grid;
  grid-template-columns: 1fr auto 1fr;
  gap: 40px;
  align-items: stretch;
}

/* Left column: icon-badge rows */
.formulation-left {
  display: flex;
  flex-direction: column;
  justify-content: space-between;
  gap: 28px;
}

.formulation-row {
  display: flex;
  align-items: flex-start;
  gap: 20px;
}

.formulation-badge {
  flex-shrink: 0;
  width: 78px;
  height: 78px;
  border-radius: 50%;
  background: linear-gradient(135deg, #006FF9, #1C479E);
  display: flex;
  flex-direction: column;
  align-items: center;
  justify-content: center;
  gap: 3px;
  color: #ffffff;
  text-align: center;
  box-shadow: 0 6px 18px rgba(0, 111, 249, 0.25);
}

.formulation-badge span {
  font-size: 0.6rem;
  font-weight: 700;
  line-height: 1.25;
  text-transform: uppercase;
  letter-spacing: 0.3px;
}

.formulation-row p {
  font-size: 0.95rem;
  color: #2d3748;
  line-height: 1.6;
  margin: 10px 0 0 0;
}

.formulation-row p strong {
  color: #1a2744;
}

/* Center divider */
.formulation-divider {
  width: 3px;
  align-self: stretch;
  background: linear-gradient(180deg, #006FF9, #1C479E);
  border-radius: 2px;
}

/* Right column: vertical stepped flow */
.formulation-right {
  display: flex;
  flex-direction: column;
  align-items: stretch;
}

.formulation-stage {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 20px;
  background: #f8fafc;
  border: 1px solid #e2e8f0;
  border-radius: 12px;
  padding: 18px 22px;
  transition: all 0.3s ease;
}

.formulation-stage:hover {
  background: #f0f7ff;
  border-color: rgba(0, 111, 249, 0.2);
}

.formulation-stage h4 {
  font-size: 0.98rem;
  font-weight: 700;
  color: #1a2744;
  margin: 0;
  line-height: 1.4;
}
.formulation-stage:hover h4{color:#000;}

.formulation-stage-visual {
  flex-shrink: 0;
  width: 56px;
  height: 56px;
  border-radius: 10px;
  background: rgba(0, 111, 249, 0.08);
  display: flex;
  align-items: center;
  justify-content: center;
  color: #006FF9;
  position: relative;
}

.formulation-stage-caption {
  position: absolute;
  bottom: -20px;
  left: 50%;
  transform: translateX(-50%);
  font-size: 0.62rem;
  color: #6b7280;
  white-space: nowrap;
  font-weight: 600;
}

.formulation-arrow-down {
  text-align: center;
  color: #94a3b8;
  font-size: 1rem;
  margin: 10px 0;
}

.formulation-stage--final {
  background: linear-gradient(135deg, #006FF9, #1C479E);
  justify-content: center;
  margin-top: 6px;
}

.formulation-stage--final h4 {
  color: #ffffff;
  text-align: center;
}

@media (max-width: 900px) {
  .formulation-grid {
    grid-template-columns: 1fr;
  }

  .formulation-divider {
    width: 100%;
    height: 3px;
    margin: 8px 0;
  }

  .formulation-left {
    gap: 24px;
  }
}

@media (max-width: 768px) {
  .formulation-badge {
    width: 64px;
    height: 64px;
  }

  .formulation-badge span {
    font-size: 0.54rem;
  }

  .formulation-row p {
    font-size: 0.85rem;
  }

  .formulation-stage {
    padding: 14px 16px;
  }

  .formulation-stage h4 {
    font-size: 0.85rem;
  }

  .formulation-stage-visual {
    width: 44px;
    height: 44px;
  }
}

/* ===== ADPKD OVERVIEW ===== */
.adpkd-section {
  padding: 100px 0;
  background: #f0f4f8;
}

.adpkd-section .section-header h2 {
  color: #1a2744;
}

.adpkd-content {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 48px;
  align-items: center;
  margin-top: 40px;
}

.adpkd-image img {
  width: 100%;
  height: auto;
  border-radius: 12px;
}

.adpkd-facts-list {
  list-style: none;
  padding: 0;
  margin: 0;
  display: flex;
  flex-direction: column;
  gap: 20px;
}

.adpkd-facts-list li {
  position: relative;
  padding-left: 20px;
  font-size: 1.05rem;
  line-height: 1.6;
  color: #2d3748;
}

.adpkd-facts-list li::before {
  content: '';
  position: absolute;
  left: 0;
  top: 10px;
  width: 8px;
  height: 8px;
  background: #006FF9;
  border-radius: 50%;
}

.adpkd-facts-list li strong {
  color: #1a2744;
}

@media (max-width: 768px) {
  .adpkd-content {
    grid-template-columns: 1fr;
    gap: 32px;
  }
}

/* ===== RENAL FIBROSIS ===== */
.renal-fibrosis-section {
  padding: 100px 0;
  background: #ffffff;
}

.renal-fibrosis-section .section-header h2 {
  color: #1a2744;
}

/* ===== COVID-19 & T2DN DUO SECTION ===== */
.pipeline-duo-section {
  padding: 100px 0;
  background: linear-gradient(135deg, #0a1628 0%, #1a2744 100%);
}

.pipeline-duo-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 48px;
}

.pipeline-duo-col {
  padding: 0;
}

.pipeline-duo-col .section-header {
  text-align: left;
  margin-bottom: 24px;
}

.pipeline-duo-col .section-header h2 {
  color: #ffffff;
  font-size: 1.4rem;
}

.pipeline-duo-col .section-badge {
  background: rgba(0,111,249,0.15);
  color: #60b4ff;
}

.pipeline-duo-content p {
  font-size: 0.95rem;
  line-height: 1.8;
  color: rgba(255,255,255,0.75);
  margin-bottom: 16px;
}

.pipeline-duo-content p strong {
  color: #ffffff;
}

@media (max-width: 768px) {
  .pipeline-duo-grid {
    grid-template-columns: 1fr;
    gap: 60px;
  }
}

/* ===== COMPETITIVE ADVANTAGE ===== */
.advantage-section {
  padding: 100px 0;
  background: var(--bg-white);
}

.advantage-column {
  display: grid;
  grid-template-columns: 60% 40%;
  gap: 40px;
}

.advantage-content p {
  margin-bottom: 20px;
  font-size: 1.1rem;
  max-width: 900px;
}

.milestones-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
  gap: 20px;
  margin: 40px 0;
}

.milestone-item {
  background: linear-gradient(135deg, #0d1a2d 0%, #1a2744 100%);
  border-radius: 16px;
  padding: 28px 24px;
  border: 1px solid rgba(0,111,249,0.2);
  border-left: none;
  position: relative;
  overflow: hidden;
  transition: all 0.3s ease;
}

.milestone-item::before {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  width: 4px;
  height: 100%;
  background: linear-gradient(180deg, #006FF9, #00C2FF);
  border-radius: 4px 0 0 4px;
}

.milestone-item::after {
  content: '';
  position: absolute;
  top: -50%;
  right: -50%;
  width: 100px;
  height: 100px;
  background: radial-gradient(circle, rgba(0,111,249,0.1) 0%, transparent 70%);
  border-radius: 50%;
}

.milestone-item:hover {
  transform: translateY(-4px);
  border-color: rgba(0,111,249,0.4);
  box-shadow: 0 12px 32px rgba(0,111,249,0.15);
}

.milestone-item .milestone-date {
  font-size: 0.85rem;
  font-weight: 800;
  color: #00C2FF;
  text-transform: uppercase;
  letter-spacing: 1.5px;
  margin-bottom: 10px;
}

.milestone-item .milestone-text {
  font-size: 1.1rem;
  color: rgba(255,255,255,0.9);
  font-weight: 600;
  line-height: 1.4;
}

.comparables-section {
  margin-top: 48px;
  padding: 40px;
  background: var(--bg-section);
  border-radius: var(--radius-lg);
}

.comparables-section h4 {
  margin-bottom: 20px;
}

.comparable-item {
  display: flex;
  align-items: center;
  gap: 16px;
  padding: 16px 0;
  border-bottom: 1px solid var(--border-light);
}

.comparable-item:last-child {
  border-bottom: none;
}

.comparable-item .comp-year {
  background: var(--gradient);
  color: #fff;
  font-weight: 700;
  font-size: 0.85rem;
  padding: 6px 14px;
  border-radius: 50px;
  white-space: nowrap;
}

.comparable-item .comp-text {
  font-size: 0.92rem;
  color: var(--text-medium);
}

/* ===== TEAM ===== */
.team-section {
  padding: 120px 0;
  background: linear-gradient(180deg, #0a0f1e 0%, #0d1a2d 50%, #0a1628 100%);
  position: relative;
  overflow: hidden;
}

.team-section::before {
  content: '';
  position: absolute;
  inset: 0;
  background:
    radial-gradient(ellipse 500px 400px at 10% 20%, rgba(0, 111, 249, 0.06) 0%, transparent 70%),
    radial-gradient(ellipse 400px 300px at 90% 80%, rgba(0, 194, 255, 0.04) 0%, transparent 70%);
  pointer-events: none;
}

.team-section .section-header h2 {
  color: #ffffff;
}

.team-section .section-badge {
  background: rgba(0, 111, 249, 0.15);
  color: #60b4ff;
}

.team-grid {
  display: flex;
  flex-direction: column;
  gap: 24px;
}

.team-card {
  background: rgba(255, 255, 255, 0.03);
  backdrop-filter: blur(12px);
  -webkit-backdrop-filter: blur(12px);
  border-radius: 20px;
  overflow: hidden;
  border: 1px solid rgba(255, 255, 255, 0.06);
  transition: all 0.4s cubic-bezier(0.4, 0, 0.2, 1);
  display: flex;
  align-items: stretch;
  position: relative;
}

.team-card::after {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  height: 1px;
  background: linear-gradient(90deg, transparent, rgba(0, 111, 249, 0.3), rgba(0, 194, 255, 0.3), transparent);
  opacity: 0;
  transition: opacity 0.4s ease;
}

.team-card:hover {
  transform: translateY(-4px);
  background: rgba(255, 255, 255, 0.05);
  border-color: rgba(0, 111, 249, 0.2);
  box-shadow: 0 20px 60px rgba(0, 0, 0, 0.3), 0 0 40px rgba(0, 111, 249, 0.06);
}

.team-card:hover::after {
  opacity: 1;
}

.team-card-img-wrap {
  position: relative;
  flex-shrink: 0;
  width: 180px;
  min-height: 220px;
}

.team-card-img {
  width: 100%;
  height: 100%;
  object-fit: cover;
  object-position: top;
  position: absolute;
  inset: 0;
}

.team-card-img-wrap::after {
  content: '';
  position: absolute;
  inset: 0;
  background: linear-gradient(90deg, transparent 70%, rgba(10, 15, 30, 0.4) 100%);
  pointer-events: none;
}

.team-card-info {
  padding: 32px 32px;
  flex: 1;
}

.team-card-info h4 {
  margin-bottom: 4px;
  font-size: 1.15rem;
  font-weight: 700;
  color: #ffffff;
  letter-spacing: -0.01em;
}

.team-card-info .role {
  display: inline-block;
  color: #60b4ff;
  font-size: 0.75rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.8px;
  margin-bottom: 16px;
  padding: 4px 12px;
  background: rgba(0, 111, 249, 0.1);
  border-radius: 4px;
  border: 1px solid rgba(0, 111, 249, 0.2);
}

.team-card-info .team-bio {
  font-size: 1rem;
  color: rgba(255, 255, 255, 0.6);
  line-height: 1.8;
}

/* ===== WHY INVESTORS ===== */
.investors-section {
  padding: 100px 0;
  background: var(--bg-white);
  position: relative;
  overflow: hidden;
}

.investors-layout {
  display: flex;
  align-items: flex-start;
  gap: 0;
}

.investors-left {
  width: 60%;
    position: relative;
    z-index: 99;
    background: #ffffffda;
    border: 1px solid #fff;
    padding: 30px;
}

.investors-right {
  position: absolute;
  top: 0;
  right: 0;
  width: 80%;
  height: 100%;
  mask-image: linear-gradient(to right, transparent 0%, black 30%);
    -webkit-mask-image: linear-gradient(to right, transparent 0%, black 30%);
}

.investors-right img {
  width: 100%;
  height: 100%;
  object-fit: cover;
}

.investors-content {
  max-width: 900px;
}

.investors-content p {
  margin-bottom: 20px;
  font-size: 1.1rem;
  color: #000;
}

/* ===== INVESTMENT HIGHLIGHTS ===== */
.invest-highlights-section {
  padding: 100px 0;
  background: #ffffff;
}

.invest-highlights-section .section-header h2 {
  color: #1a2744;
}

.invest-hl-stack {
  max-width: 900px;
  margin: 0 auto;
  display: flex;
  flex-direction: column;
  gap: 0;
}

.invest-hl-group {
  display: flex;
  margin-bottom: 24px;
}

.invest-hl-sidebar {
  width: 48px;
  background: linear-gradient(180deg, #006FF9, #1C479E);
  border-radius: 12px 0 0 12px;
  display: flex;
  align-items: center;
  justify-content: center;
  flex-shrink: 0;
}

.invest-hl-sidebar-label {
  color: #ffffff;
  font-weight: 900;
  font-size: 1.1rem;
  letter-spacing: 2px;
  line-height: 1.6;
  text-align: center;
}

.invest-hl-items {
  flex: 1;
  display: flex;
  flex-direction: column;
  gap: 0;
}

.invest-hl-row {
  display: flex;
  align-items: center;
  gap: 24px;
  padding: 24px 28px;
  border: 1px solid #e2e8f0;
  border-left: none;
}

.invest-hl-items .invest-hl-row:first-child {
  border-radius: 0 12px 0 0;
}

.invest-hl-items .invest-hl-row:last-child {
  border-radius: 0 0 12px 0;
}

.invest-hl-items .invest-hl-row + .invest-hl-row {
  border-top: none;
}

.invest-hl-row--blue {
  border: 1px solid #e2e8f0;
  border-radius: 12px;
  margin-bottom: 0;
  margin-top: -1px;
  border-left: 5px solid #006FF9;
}

.invest-hl-row p {
  font-size: 1.1rem;
  line-height: 1.6;
  color: #2d3748;
  margin: 0;
}

.invest-hl-row p strong {
  color: #006FF9;
}

.invest-hl-tag {
  flex-shrink: 0;
  width: 100px;
  padding: 14px 8px;
  text-align: center;
  font-size: 0.75rem;
  font-weight: 800;
  letter-spacing: 0.5px;
  border-radius: 8px;
  line-height: 1.3;
}

.invest-hl-tag--light {
  background: #f0f4f8;
  color: #1a2744;
}

.invest-hl-tag--medium {
  background: #e2e8f0;
  color: #1a2744;
}

.invest-hl-tag--dark {
  background: #cbd5e0;
  color: #1a2744;
}

.invest-hl-tag--blue {
  background: linear-gradient(135deg, #006FF9, #1C479E);
  color: #ffffff;
  width: 110px;
  padding: 18px 12px;
}

.invest-hl-tag--blue-dark {
  background: linear-gradient(135deg, #1C479E, #0a1628);
  color: #ffffff;
  width: 110px;
  padding: 18px 12px;
}

@media (max-width: 768px) {
  .invest-hl-group {
    flex-direction: column;
  }

  .invest-hl-sidebar {
    width: 100%;
    height: 40px;
    border-radius: 12px 12px 0 0;
    flex-direction: row;
  }

  .invest-hl-sidebar-label {
    display: flex;
    gap: 4px;
  }
    .invest-hl-sidebar-label br {display: none;}

  .invest-hl-items .invest-hl-row:first-child {
    border-radius: 0;
  }

  .invest-hl-items .invest-hl-row:last-child {
    border-radius: 0 0 12px 12px;
  }

  .invest-hl-items .invest-hl-row {
    border-left: 1px solid #e2e8f0;
  }

  .invest-hl-row {
    flex-direction: column;
    align-items: flex-start;
    gap: 12px;
  }
}

/* ===== IN SUMMARY ===== */
.summary-section {
  padding: 100px 0;
  background: linear-gradient(160deg, #0a1628 0%, #1C479E 50%, #006FF9 100%);
  position: relative;
  overflow: hidden;
}

.summary-section::before {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  bottom: 0;
  background: 
    radial-gradient(circle at 30% 20%, rgba(0, 194, 255, 0.08) 0%, transparent 50%),
    radial-gradient(circle at 70% 80%, rgba(0, 111, 249, 0.1) 0%, transparent 50%);
}

.summary-content {
  position: relative;
  z-index: 2;
  max-width: 900px;
  margin: 0 auto;
  text-align: center;
}

.summary-content h2 {
  color: #fff;
  margin-bottom: 40px;
}

.summary-content p {
  color: rgba(255, 255, 255, 0.85);
  font-size: 1.05rem;
  margin-bottom: 24px;
  line-height: 1.9;
}

/* ===== LATEST NEWS ===== */
.news-section {
  padding: 100px 0;
  background: var(--bg-section);
}

.news-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(320px, 1fr));
  gap: 24px;
}

.news-card {
  background: var(--bg-white);
  border-radius: var(--radius-lg);
  padding: 32px;
  box-shadow: var(--shadow-card);
  border: 1px solid var(--border-light);
  transition: var(--transition);
}

.news-card:hover {
  transform: translateY(-4px);
  box-shadow: var(--shadow-lg);
}

.news-card .news-source {
  font-size: 0.75rem;
  font-weight: 600;
  color: var(--primary);
  text-transform: uppercase;
  letter-spacing: 1px;
  margin-bottom: 12px;
}

.news-card h4 {
  font-size: 1.2rem;
  line-height: 1.5;
  margin-bottom: 16px;
}

.news-card a {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  font-size: 0.95rem;
  font-weight: 600;
}


/* Chart and footer */


.charts, .source, .section19{background-color: #ffffff; color: #4a6478;}
.source h4, .section19 h3,.section19 h5{color: #1a2d4a; padding-bottom: 15px;}
.charts .container {
    display: flex;
    flex-wrap: wrap;
    justify-content: space-between;
}
.chartone {
    width: 100%;
    margin-bottom: 30px;
}
.chart.charttwo {
    width: 48%;
}
.tradingview-widget-container {
    max-width: 100%;
    overflow: hidden;
}
.chart.charttwo iframe {
    height: 500px !important;
    width: 100% !important;
}
@media (max-width: 767px) {
    .chart.charttwo {
        width: 100%;
        margin-bottom: 15px;
    }
}
.padt80 {
    padding-top: 80px;
}
#footnote, #section19 {
    word-break: break-word;
    font-size: 14px;
}

.relative {
    position: relative;
}
.z-index {
    z-index: 1;
}
.text-left {
    text-align: left;
}
.padt40 {
    padding-top: 40px;
}
.text-center {
    text-align: center;
}

footer {
    background: var(--primary-dark);
    color: #fff;
    font-size: 14px;
    padding: 10px 0;
}


/* ===== FOOTER ===== */
.site-footer {
  background: #142028;
  border-top: 1px solid var(--border);
  padding: 25px 0;
  text-align: center;
}
.site-footer p {
  font-size: 0.8rem;
  color: var(--text-muted);
  line-height: 1.6;
}

/* ===== FOOTER ===== */
.footer {
  padding: 40px 0;
  background: var(--text-dark);
  text-align: center;
}

.footer p {
  color: rgba(255, 255, 255, 0.5);
  font-size: 0.85rem;
}

.footer a {
  color: rgba(255, 255, 255, 0.7);
}

.footer a:hover {
  color: var(--accent);
}

/* ===== BACK TO TOP ===== */
.back-to-top {
  position: fixed;
  bottom: 30px;
  right: 30px;
  width: 48px;
  height: 48px;
  background: var(--gradient);
  border-radius: 50%;
  display: flex;
  align-items: center;
  justify-content: center;
  color: #fff;
  font-size: 1.2rem;
  box-shadow: var(--shadow-md);
  cursor: pointer;
  opacity: 0;
  visibility: hidden;
  transition: var(--transition);
  z-index: 999;
  border: none;
}

.back-to-top.visible {
  opacity: 1;
  visibility: visible;
}

.back-to-top:hover {
  transform: translateY(-3px);
  box-shadow: var(--shadow-lg);
}

/* ===== RESPONSIVE ===== */
@media (max-width: 1024px) {
  .overview-content,
  .company-content {
    grid-template-columns: 1fr;
    gap: 20px;
  }

  .ps-panel {
    min-height: auto;
  }

  .ps-panel-bg {
    background-attachment: scroll;
  }

  .ps-panel-content {
    padding: 60px 5%;
  }

  .ps-panel--problem .ps-panel-content,
  .ps-panel--solution .ps-panel-content {
    justify-content: center;
  }

  .ps-floating-card {
    max-width: 100%;
  }

  .ps-card-body {
    padding: 32px 24px;
  }

  .market-stats {
    grid-template-columns: repeat(2, 1fr);
  }

  .company-sidebar {
    position: static;
  }
}

@media (max-width: 768px) {
  .navbar {
    padding: 8px 0;
  }

  .navbar .container {
    padding: 0 16px;
    max-width: 100%;
  }

  .nav-logo img {
    height: 48px;
  }

  .hero-ticker {
    padding: 8px 16px;
    gap: 8px;
    border-radius: 30px 0;
  }

  .hero-ticker .dot {
    width: 8px;
    height: 8px;
  }

  .hero-ticker span {
    font-size: 0.9rem;
    letter-spacing: 1px;
  }

  .hero {
    min-height: auto;
    padding: 120px 0 00px;
    flex-direction: column;
  }

  .hero::after {
    width: 100%;
    opacity: 0.12;
    mask-image: none;
    -webkit-mask-image: none;
  }

  .hero-content {
    width: 100%;
    padding: 0 16px;
    text-align: center;
  }

  .nav-advertorial {
    font-size: 0.6rem;
    padding: 5px 10px;
    letter-spacing: 1px;
    margin-bottom: 14px;
  }

  .hero h1 {
    font-size: 1.4rem;
    line-height: 1.5;
    margin-bottom: 16px;
  }

  .hero-desc {
    font-size: 0.88rem;
    line-height: 1.7;
    margin-bottom: 20px;
  }

  .hero-blob {
    width: 300px;
    height: 300px;
  }

  .hero-particles {
    display: none;
  }

  #ct {
    position: relative;
    bottom: auto;
    width: 100%;
    font-size: 9px;
    line-height: 13px;
    padding: 10px 16px;
    margin-top: 20px;
  }

  .hl-grid {
    grid-template-columns: 1fr;
  }

  .hl-card--wide {
    grid-column: span 1;
  }

  .reasons-grid {
    grid-template-columns: 1fr;
  }

  .reason-card--featured {
    grid-column: span 1;
  }

  .market-stats {
    grid-template-columns: 1fr 1fr;
  }

  .section-header {
    margin-bottom: 40px;
  }

  .pipeline-grid {
    margin-left: 20px;
  }

  .pipeline-card {
    margin-left: 24px;
  }

  .pipeline-card::after {
    left: -26px;
    width: 12px;
    height: 12px;
  }

  .pipeline-card-body {
    padding: 24px;
  }

  .pipeline-progress {
    display: none;
  }

  .team-card {
    flex-direction: column;
  }

  .team-card-img-wrap {
    width: 100%;
    min-height: 200px;
    height: 200px;
  }

  .team-card-img-wrap::after {
    background: linear-gradient(180deg, transparent 60%, rgba(10, 15, 30, 0.6) 100%);
  }

  .milestones-grid {
    grid-template-columns: 1fr;
  }

  .overview-image::after{right: 0;}
}

@media (max-width: 480px) {
  .team-grid {
    grid-template-columns: 1fr;
  }

  .hero-compensation {
    font-size: 0.6rem;
  }
}

@media (max-width: 768px) {
  .investors-layout {
    flex-direction: column;
  }

  .investors-left {
    width: 100%;
    padding: 20px;
  }

  .investors-right {
    position: relative;
    width: 100%;
    height: 250px;
    mask-image: none;
    -webkit-mask-image: none;
  }

  .advantage-column {
    grid-template-columns: 1fr;
    gap: 24px;
  }

  .section-header h2 {
    font-size: 1.4rem;
  }

  .section-badge {
    font-size: 0.7rem;
    padding: 6px 14px;
  }

  .investor-overview,
  .strategic-section,
  .market-section,
  .company-section,
  .growth-section,
  .pipeline-chart-section,
  .gout-section,
  .adpkd-section,
  .renal-fibrosis-section,
  .advantage-section,
  .investors-section,
  .invest-highlights-section,
  .news-section {
    padding: 60px 0;
  }

  .highlights-section,
  .reasons-section,
  .team-section,
  .pipeline-section {
    padding: 80px 0;
  }

  .strategic-quote {
    padding: 28px 24px 28px 32px;
    margin: 24px 0;
  }

  .strategic-quote p, .adpkd-facts-list li {
    font-size: 1rem;
  }

  .strategic-quote .quote-author {
    flex-direction: column;
    align-items: flex-start;
    gap: 12px;
  }

  .strategic-quote .quote-author-img {
    width: 44px;
    height: 44px;
  }

  .market-content p {
    font-size: 1rem;
  }

  .market-cta {
    padding: 20px 24px;
  }

  .market-cta p {
    font-size: 1rem;
  }

  .stat-card {
    padding: 20px 16px;
  }

  .stat-card .stat-number {
    font-size: 1.6rem;
  }

  .stat-card .stat-label {
    font-size: 0.75rem;
  }

  .reason-card {
    padding: 24px 20px 20px;
  }

  .reason-card::before {
    font-size: 3.5rem;
    top: -8px;
    right: 10px;
  }

  .reason-card h4 {
    font-size: 0.95rem;
    padding-right: 40px;
  }

  .reason-card p {
    font-size: 1rem;
  }

  .company-text {
    padding: 24px 20px;
  }

  .company-text p {
    font-size: 1rem;
  }

  .company-sidebar-card {
    padding: 28px 24px;
  }

  .growth-card {
    padding: 28px 20px;
    gap: 20px;
  }

  .growth-icon {
    width: 56px;
    height: 56px;
  }

  .growth-content h3 {
    font-size: 1.2rem;
  }

  .growth-content p {
    font-size: 1rem;
  }

  .news-grid {
    grid-template-columns: 1fr;
  }

  .news-card {
    padding: 24px 20px;
  }

  .news-card h4 {
    font-size: 1rem;
  }

  .summary-section {
    padding: 60px 0;
  }

  .summary-content h2 {
    font-size: 1.4rem;
  }

  .summary-content p {
    font-size: 1rem;
  }

  .comparables-section {
    padding: 24px 20px;
    margin-top: 32px;
  }

  .comparable-item {
    flex-direction: column;
    align-items: flex-start;
    gap: 8px;
  }

  .comparable-item .comp-text {
    font-size: 0.85rem;
  }

  .milestone-item {
    padding: 20px 18px;
  }

  .milestone-item .milestone-text {
    font-size: 1rem;
  }

  .ps-card-body h3 {
    font-size: 1.2rem;
  }

  .ps-card-body p {
    font-size: 1rem;
  }

  .febuxostat-section,
  .gout-landscape-section,
  .gout-plan-section,
  .oxypurinol-section {
    padding-top: 48px;
  }

  .charts .container {
    flex-direction: column;
  }

  .chart.charttwo {
    width: 100%;
    margin-bottom: 15px;
  }

  .overview-image {
    margin-top: 32px;
  }

  .container {
    padding: 0 16px;
  }
}

@media (max-width: 480px) {
  .team-grid {
    grid-template-columns: 1fr;
  }
  .team-card-info {
    padding: 24px 16px;
  }
  .team-card-img-wrap {
    width: 100%;
    min-height: 350px;
    height: auto;
  }

  .hero-compensation {
    font-size: 0.6rem;
  }

  .hero {
    padding: 100px 0 0px;
  }

  .hero h1 {
    font-size: 1.3rem;
    line-height: 1.5;
  }

  .hero-desc {
    font-size: 0.82rem;
  }

  .hero-ticker {
    padding: 6px 12px;
    margin-bottom: 0;
    border-radius: 20px;
  }

  .hero-ticker span {
    font-size: 1rem;
  }

  .nav-logo img {
    height: 36px;
  }

  .nav-advertorial {
    font-size: 0.55rem;
    padding: 4px 8px;
  }

  .section-header h2 {
    font-size: 1.2rem;
  }

  .stat-card .stat-number {
    font-size: 1.4rem;
  }

  .growth-highlights {
    flex-direction: column;
    gap: 12px;
  }

  .growth-highlight-item {
    padding: 12px 16px;
  }

  .investors-left {
    padding: 16px;
  }

  .investors-content p {
    font-size: 1rem;
  }

  .advantage-content p {
    font-size: 1rem;
  }
  .overview-text p{font-size: 1rem;}

  .back-to-top {
    bottom: 16px;
    right: 16px;
    width: 40px;
    height: 40px;
  }
}